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The increased expression of immune checkpoint ligand levels in TAMs (such as PD-L1 and PD-L2, etc.) can directly inhibit the activity of T cells

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Together, these results suggest that high inflammatory phenotypes induced by succinate, which can be evident in various mitochondrial diseases, contribute to microbial dysbiosis

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We plan to provide implementation instructions for our contractors that will include coding and payment instructions, through the CMS Transmittals online platform