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doi: 10.3389/fimmu.2018.00141 11 MaierTJenniSBanN

This decline isn't just a normal part of agingit's a major contributor to the aging process itself

Compared to clinical trials on DNA methylation as a diagnostic biomarker, the limited number of clinical studies investigating DNA methylation as a prognostic marker indicates that the role of DNA methylation in cancer prognosis remains insufficiently explored