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O 2 further undergoes dismutation reaction catalyzed by SOD or O 2 can be reduced by PQH 2 (see above), to produce H 2 O 2 , which in turn is reduced by Asc with the involvement of ascorbate peroxidase (APX), generating H 2 O and monodehydroascorbate radical (MDHA) (Figure 5)

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The project was directed by MR and HFN who also wrote the manuscript

However, to date, there are no FDA-approved treatments available for all patients with ALD, especially those who will ultimately develop one of the ALD phenotypes in the later decades of life