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Interventions aimed at reducing inflammation in animal models of ASD have been shown to have a positive effect on behavior and cognition, whilst simultaneously reducing neuroinflammation and supporting the restoration of neuronal integrity in key brain regions

SJ Padayatty, AY Sun, Q Chen, et al

Furthermore, it remains elusive whether GSH is upregulated or downregulated as a result of metabolic activity (including blood oxygenation and brain excitability) induced by cognitive effort

Experiments have shown that 252 the accumulation of lactate in the TME entails acidification of the TME, and a lower extracellular pH has been shown to impair almost all aspects of CD8 + and CD4 + T lymphocyte function, including the activation of cytotoxicity, chemotactic motility, and proliferation 253,254