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Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: effects on ERK1/2, JNK, and Akt pathways

Correlation analysis Finally, as shown in Tables 4 and 5 , TAC, MDA, SOD, and CAT concentrations in serum and FF were analyzed for correlations

however, in specific genetic contexts, its abnormal splicing or functional inactivation may lead to insufficient intracellular iron accumulation, thereby limiting Fenton reaction efficiency and attenuating radiotherapy-induced lipid peroxidative damage (196).Conversely, overexpression of ACSL3, a member of the long-chain fatty acid-CoA ligase family, enhances the activation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), promoting the synthesis of oxidation-sensitive phospholipids like AA-PE and significantly increasing membrane susceptibility to radiotherapy-induced lipid peroxidation (197)