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It was removed from Category 2 on April 23, 2026 and is on the July 23, 2026 PCAC agenda

In addition, pyruvate, a key glycolytic metabolite generated by pyruvate kinase muscle 2 isoform (PKM2), directly supports the DDR by facilitating -H2AX loading through the FACT (facilitates chromatin transcription) complex, thereby promoting DNA repair efficiency and conferring radioresistance [75]