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RAGE against the glycation machine in synucleinopathies: time to explore new questions

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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon

Its sequence comes from a small fragment of a larger protein found in human gastric juice, the digestive fluid produced by the stomach