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Potential CNS Access : Some research suggests nasal administration may facilitate direct transport to the central nervous system via olfactory and trigeminal nerve pathways, though this remains an area of ongoing investigation [5]

For mice requiring gene therapy, lentiviruses expressing FOXO3 were intra-articularly injected

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For example, studies demonstrated that A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in ADHD, compared with a 1.3-fold increase for the C677T genotype 85 , individuals with ADHD seem to be related to A1298C polymorphisms 86