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Thus, 275 mg/m 3 Tolerable concentration = = 0.3 mg/m 3 (300 g/m 3 ) 1000 where: 275 mg/m 3 was the NOEL for irritation in rats in a 4-week study (Appelman et al., 1986) and 1000 is the uncertainty factor (10 for interspecies variation, 10 for intraspecies variation and 10 for a less than long-term study and severity of effect, i.e., carcinogenicity associated with irritation)

Accelerated eryptosis might be associated with anemia due to rapid clearance of eryptotic cells via efferocytosis, activation of blood clotting, and damage to endothelial cells caused by adherence of eryptotic cells to them (Fig

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[PMC free article: PMC3428121] [PubMed: 22267330] 886