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TABLE 4 Results of Histopathological scoring in all the study groups

In the setting of high ROS, as is seen with G6PD-inhibition, heme production has been shown to be impaired 137

Parallel to identification of Mn neurotoxic properties, neuroprotective strategies have been reported, and these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols and non-characterized components), iron chelating agents, precursors of glutathione (GSH), and synthetic compounds that can experimentally afford protection against Mn-induced neurotoxicity

reported that pregnant women who experience intrahepatic cholestasis of pregnancy (ICP): intense itching in late pregnancy due to liver condition, are considered to be at risk of vitamin K deficiency as shown in Fig