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The 2026 broader peptide-therapy reviews (PMID 41966639) place this compound class in the wider research-context of unapproved compounds under active investigation

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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

5,6,7,8,19,21 Yet, how these phenotypically distinct cell and mCRPC subtypes adapt to survive AR-targeted therapiesand whether they share common, targetable resistance programsremains poorly understood