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doi: 10.1016/j.scitotenv.2021.146885 Summary Keywords metabolomics, microplastics, oxidative stress, placenta, polystyrene Citation de Sousa AKA, Pires KSN, Cavalcante IH, Cavalcante ICL, Santos JD, Queiroz MIC, Leite ACR, Crispim AC, da Rocha Junior ER, Aquino TM, Weingrill RB, Urschitz J, Ospina-Prieto S and Borbely AU (2024) Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations

It is a highly reactive toxic metabolite formed by cytochrome P450 2E1 and is responsible for the hepatocellular injury that occurs with paracetamol toxicity

At 1 day, we measured effective and robust uptake of particles formed at both 0.2 and 2 mg/mL, averaging uptake of nearly 40 particles per cell at higher concentrations (Fig

In the presence of reactive oxygen species, these organisms shift to efficient aerobic respiration, giving them a competitive advantage over beneficial obligate anaerobes and allowing them to replace them