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Sin embargo, en la histopatologa se presenta un aumento de los melanocitos, los cuales son claramente atpicos, pudiendo mostrar diseminacin pagetoide y frecuentemente invasin de la lmina propia

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[7] In tobacco-users the melanocytes are stimulated to produce melanin granules and to distribute them out to the surrounding epithelial cells for further transport to the mucosal surface, like the mechanism in melanin-pigmented skin