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After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated

Coordination changes and affected judgment are commonly reported at this level, though individual responses vary by body weight, biological sex, and tolerance

Other side effects of an overdose of vitamin B1 are irritability, headache, tremors, and palpitations

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