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Overdose Symptoms such as nausea, vomiting, or dizziness may occur

Conclusion: Altogether, our results show that the cellular antioxidant defense systems contribute to leukemia resistance to MTX, and targeting these pathways, especially the thioredoxin antioxidant system, may be a promising strategy for resensitizing ALL to MTX

Pharmacokinetic limitations, such as rapid metabolism and short half-lives, further complicate achieving therapeutic concentrations within brain tumors while minimizing systemic toxicity

As patients find their voice and providers are forced to confront the limitations of our current approach, a shift to a patient-centered paradigm will be essential and inevitable