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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Pirozzi F.F., Belini Junior E., Okumura J.V., Salvarani M., Bonini-Domingos C.R., Ruiz M.A

To address this, we additionally deleted the gene coding for Ggt in these cells and analyzed reduction of Grx1-roGFP2 by exogenous GSH in the resulting gshA gsiC ggt triple deletion mutant

Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig

Abstract Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the worlds poorest children and women of childbearing ages across regions of sub-Saharan Africa