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Based on the pronounced protective effects of Cacna1c knockdown and LTCC blockade, it has to be taken into consideration that, beyond its influence on calcium homeostasis at the plasma membrane, Cacna1c is possibly involved in further regulatory pathways at the level of mitochondria

The fact that cysteine S -conjugate -lyase activity is widespread in enteric bacteria and that a major portion of cysteine S -conjugates are excreted into the bile suggests that the gut flora may be important for the incorporation of sulfur into some xenobiotics (Larsen and Stevens, 1986)