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Although phosphorylation of -syn has been shown to induce cytotoxicity and promotes the formation of Lewy bodies, its exact role in PD pathology remains ambiguous (Ramalingam et al

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Insulin also significantly increased the MR effect on CHAC1 and SLC7A5 expression but had no effect on other ATF4-responsive genes shown to be sensitive to mTOR (e.g., PSAT1, ASNS, CARS, MARS, SESN2, EIF4EBP1, and DDIT4 (data not shown))

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