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Neuroscience 335 , 207220 (2016)

Additionally, a negative correlation between complex II activity and oxidative stress measures has been reported in BD patients during depressive episodes, suggesting that mitochondrial oxidative stress related mitochondrial dysfunction may contribute to bipolar depression [50]

Considering these studies utilised the same dose and timing of ingestion as other studies demonstrating ergogenic effects in resistance exercise performance, the use of CM seems ineffective at improving cycling performance in trained individuals