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The JAMA clinical study demonstrated statistically significant visceral adipose tissue reduction in treated patients

Pulsatile GH patterns are important for optimal receptor sensitivity and metabolic effects - continuous GH exposure can lead to receptor downregulation and may have different metabolic consequences than pulsatile patterns

GHRP-6 treatment, initiated post-surgery and continued for 7 days, attenuated LV wall thinning and ventricular ballooning, reduced myocardial interstitial fibrosis on histology, and improved ejection fraction and fractional shortening on echocardiography versus saline controls

However, in clinical practice, troublesome GERD symptoms persist in 20 30% of patients despite daily treatment with a proton pomp inhibitor (PPI)