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Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats

The mice were randomly divided into eight groups: control, vehicle, positive control (0.15 g/kg silymarin), glutathione (0.0166 g/kg), Ganoderma lucidum (Gan, 0.0666 g/kg), vitamin C (0.0666 g/kg), and GGV groups at two doses (0.15 g/kg, 0.45 g/kg)

Dosages are typically between 600 mg and 2400 mg per session, administered 1-3 times per week

The zebrafish has emerged as a particularly valuable model for deciphering this complexity and screening therapeutic candidates, as it allows for the rapid establishment of pathology through various dietary and chemical means that recapitulate key features of human MASLD