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Understanding these genetic nuances provides critical insights into the molecular basis of skin appendage development and offers potential therapeutic targets for conditions affecting hair and nails

As a result, most if not all IgG4 MuSK antibodies are monovalent, rather than divalent, for their antigen (Koneczny et al., Figure 2 With the discovery of MuSK as the antigen, both in vitro and in vivo models provided strong evidence of the pathogenicity of MuSK antibodies

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In order to collect a sufficient number of cells for implantation, isolated chondrocytes usually undergo an extensive expansion from 0.10.2 million to 4060 million ( Thus, selectively removing senescent cells in chondrocytes is crucial to assure the quality of cells for ACI