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From a genetic standpoint, methylation can cause genes to either express, or become "silent"

doi: 10.1016/j.isci.2023.106862

Image from Kraskovskaya et al

In a Medicare cohort, dementia prevalence rose from 28% at age 66 to 70% by age 80 in schizophrenia, compared with 1.3 and 11.3% in matched controls (12)