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Lactate also regulates other immune cells in the TME, such as MDSCs and DCs

While Ishikawa and Ali-Osman [14] initially reported that formation of Pt(GS) 2 complex reached a maximal level after 12 hrs in L1210 cells treated with 20 M CDDP, corresponding to ~60% of the intracellular Pt content, however, Berners-Price and Kuchel studied the reaction of CDDP with GSH inside intact red blood cells using 1 H spin-echo nuclear magnetic resonance (NMR) and detected no formation of Pt-GSH bonds within 4 hrs of incubation [26]

In general, the secretion of synuclein in degenerating neurons is greatly increased compared with that of healthy neurons, and alpha-synuclein has enhanced immune characteristics when oxidized or nitrated

Science 257 , 401403 (1992)