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It was first registered in Austria in 1962 and is now the world leader in vitamin B combination products[1]

doi:10.1016/j.mrfmmm.2005.02.020

Zhou and co-authors have reported that purified fruit bromelain could stop epithelial TNF- receptors in rat colitis models and intestinal cell line IEC-6 and Caco-2 cells ( Bromelain can accelerate tissue repair processes as a result of the depolymerization of intercellular structures and modification of vascular permeability (135)