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Despite their diverse pharmacological properties, these drugs converge on shared neurotoxic pathways, including oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation

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The metabolic adaptations that occur are limited to the enhanced expression of beta-3 adrenergic receptors in adipose tissue, which actually represents a favorable metabolic improvement rather than a dependence-creating change

The authors stratified their results based on the severity of hepatic encephalopathy at the time of inclusion and demonstrated that NAC-treated patients with mild hepatic encephalopathy (grade I and II) had better survival compared to controls