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The inhibition of system xc - significantly reduces GSH production, thereby decreasing GPX4 activity, leading to lipid ROS build-up and ultimately leading to ferroptosis ( Figure 1B )

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This suggests that Gstm1 and Gstt1 play critical roles in modulating oxidative stress and ferroptosis in cisplatin-induced AKI

Vitamin C helps "recharge" glutathione after it has neutralized a free radical, making your supplement work harder for you