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Nitric oxide also plays a role in iron trafficking because it mimics the consequences of iron starvation and triggers iron uptake by cells

Secondly, asparaginase depletion using L-asparaginase has been a very effective approach in treating hematologic malignancies with detailed toxicity profile and well-studied resistance mechanism

71 Therapeutic modulation of the autophagy-mitophagy axis in metabolic diseases Pharmacological interventions Several pharmacological agents already in clinical use exert metabolic benefits, at least in part, through activation of autophagy and mitophagy