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Oncotarget 7 (35), 5629556308

Headache Mild stomach upset Flatulence Nausea and vomiting Patients with bipolar disorder may develop mania Patient Warnings: Patients taking selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, or other drugs that affect serotonin levels should avoid taking SAM-e without the supervision of a physician due to case reports of mania and serotonin syndrome, a serious condition, or other side effects

Importantly, we found that CHAC1 expression is significantly upregulated in skeletal muscles under various wasting conditions, including cancer induced cachexia, chemo-agent cisplatin induced cachexia, and fasting induced muscle atrophy

doi:10.1016/j.jaut.2024.103246