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4.3 GSH-sensitive drug release in vitro It is well established that the tumor microenvironment possesses a significant reducing potential, as the intracellular concentrations of glutathione (GSH) (111 mM) are markedly higher than those in the extracellular space (2 M)

Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells

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