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Metabolic dysfunction (and the more severe metabolic syndrome) are exacerbated by modern lifestyle and dietary habits, leading to chronic inflammation and oxidative stress, which further degrade cell functioning

Although zebrafish liver disease models are widely employed, a dedicated methodological synthesis evaluating their application specifically for phytochemical researchfrom model establishment to mechanistic validationis lacking

Future studies should test whether NRF2 activation can effectively reduce PC and preserve functional -cells in diabetes