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In the last three decades, we have witnessed increased commercial efforts in transforming cell-free Hb to an oxygen-carrying (HBOC) therapeutic to be used in lieu of RBCs in transfusion medicine

doi: 10.1158/1538-7445.AM2020-4373 [DOI] [Google Scholar] 260

Instead, it exerts selective pressure that drives the emergence of metabolically resilient subpopulations, thereby negating the intended genotoxic impact and leading to disease recurrence