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Description

It can result from ailments like chronic kidney disease, cancer, bone marrow issues, and specific medications

Environ Exp Bot 161:180192

Signaling pathways modulated by glutathione NRF2/KEAP1 antioxidant response: Oxidation or Sglutathionylation of Keap1 cysteines impairs Nrf2 ubiquitination, allowing Nrf2 stabilization, nuclear translocation, and induction of ARE-driven genes, including GCL subunits, the cystine/glutamate antiporter xCT, and GST isoformscreating a feed-forward elevation of GSH synthesis and conjugation capacity