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A total of 268 genes were differentially expressed in response to Palbociclib treatment (184 downregulated, 84 upregulated), 6028 genes in response to Telaglenastat (3290 downregulated, 2738 upregulated), and 4774 genes in response to the combined treatment (2527 downregulated, 2247 upregulated), compared to the control group (Supplementary Fig

By observing serum insulin secretion and blood glucose concentration in rats, it was found that L-theanine downregulated the expression of SGLT3 and GLUT5 in the intestinal tract, leading to the inhibition of glucose uptake in the small intestine (78)