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Experimental NNMT inhibition with compounds such as 5-Amino-1MQ has been reported to correlate with: Reduced fat cell size and changes in fat mass in diet-induced models Shifts in metabolic efficiency and energy utilization Altered expression of glucose transporters (including GLUT4) in skeletal muscle and fat tissue Some studies have observed notable changes in body mass and adipose tissue over relatively short experimental periods without modifications in food intake

This typically subsides as the body adjusts and can be managed by staying well-hydrated and monitoring sodium intake

For example, a daily dose of 500-1000 mcg might work for mild symptoms

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