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To further characterise glucose homeostasis we subjected chow-fed lox/lox and HGKO mice to hyperinuslinaemiceuglycaemic clamps (Fig

In the following years, several studies confirmed that the reduction of intracellular cysteine content and the massive consumption of GSH played a key role in inducing cell death and proved that lipophilic antioxidants and iron chelators can inhibit such death way, these are the main features of ferroptosis ( Figure 2 )

This phenotype was manifested in the accumulation of lactic acid, pyruvate, and carnitine, increased alanine aminotransferase and aspartate aminotransferase levels in plasma [72], suppressed ETC activity, and reduced mitochondrial membrane potential ( m ) [79]

Walker BJ, Strand DD, Kramer DM, Cousins AB (2014) The response of cyclic electron flow around photosystem i to changes in photorespiration and nitrate assimilation