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Activation of NF-B, for instance, promotes the transcription of genes encoding a wide array of pro-inflammatory mediators, including cytokines (e.g., TNF-, IL-1, IL-6, IL-18) and chemokines (e.g., MCP-1, IL-8) (Liu et al., 2020)

BioEssays 39:240

The combined quinone redox glutathione metabolism model can be used to simulate experimentally challenging scenarios such as potential redox cycling toxicity, while providing a platform from which quinone exposure and concentration toxicity experiments may be guided