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Bioeng 2020, 13, 463474

A similar state is observed in rheumatoid arthritis (RA) patients, where T cell-mediated dysregulation has become an important model system for studying the functional influence of ROS on T-cell functions

The noncatalyzed reaction is slow (in the order of k =0.110 M 1 s 1 at pH 7, see Table 1) (30, 56, 93, 100), but oxidoreductase enzymes [such as thioredoxin (Trx), glutaredoxin (Grx), the bacterial disulfide bond protein family A-D (DsbA-D), protein disulfide isomerase (PDI), Mia40, ER oxidoreductin (Ero1), essential for respiration and vegetative growth sulfhydryl oxidase, Erv1, see Figs

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