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doi: 10.1007/s00210-019-01702-6 153 Matsuu-MatsuyamaMShichijoKTsuchiyaTKondoHMiuraSMatsudaKet al

These conditions lead to the accumulation of misfolded proteins and activation of the unfolded protein response (UPR) [9], impairing protein synthesis and increasing chaperone production [72]

According to a 2005 study, 5% of American women and 12% of men will develop a kidney stone at some time in their life, and prevalence has been rising in both sexes.[ref] Urinary crystals can also form in urine that contains calcium and oxalates

Here, we delve into the interplay and mechanisms between the biological barrier, comprised of gut microbiota, and other barriers