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81 Notably, Wnt5a, a common nonclassical Wnt pathway activator, after secretion by fibroblasts, activates the classic Wnt signalling pathway in AT2 cells and inhibits the transdifferentiation of AXIN2 + AT2 cells with stem cell activity into AT1 cells, thus maintaining the dryness of AT2 cells

Clin J Am Soc Nephrol 10 , 147155 (2015)

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Bottom line: For long-term hair and scalp health, combine high-bioavailability supplementation with a diet rich in sulfur-containing vegetables and a lifestyle that minimizes unnecessary oxidative stress