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Strengths and limitations One limitation of this study was the small sample size of 12 participants

Interestingly, among patients with severe COVID-19 treated with darunavir, a CYP3A4 substrate, it was shown that high IL-6 levels significantly decrease drug clearance [38]

Two researchers independently performed a preliminary screening of the titles and abstracts of all retrieved documents, and then read the full text of the documents screened in the first round to conduct a second screening based on the inclusion criteria, while recording the reasons for rejection

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