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2 Yao JK, Leonard S, Reddy R: Altered glutathione redox state in schizophrenia

Within the ER (endoplasmic reticulum), there are processes that check to make sure that proteins are made and folded correctly

2272-C ACCELERATION OF AN ADVANCED NASH MODEL BY ACUTE AND TOXIC EFFECTS OF PHENOBARBITAL Nico Kraus 1 , Magnus Moeslein 1 , Robert Schierwagen 1,2 , Wenyi Gu 1,2 , Maximilian Joseph Brol 1,2 , Frank Erhard Uschner 1,2 , Pierre-Emmanuel Rautou 3,4 , Sophie Lotersztajn 5,6 , Roger Flores-Costa 7 , Joan Claria 7,8 , Jonel Trebicka 1,2,8 and Sabine Klein 1,2 , (1)University Hospital Frankfurt, (2)University Hospital Mnster, (3)Hpital Beaujon, (4)Universit Paris-Cit, (5)Inserm, (6)Sorbonne Paris Cit, (7)Hospital Clnic-Idibaps, Barcelona, Spain, (8)European Foundation for the Study of Chronic Liver Failure Background: Non-alcoholic steatohepatitis (NASH) is an increasing cause for liver cirrhosis globally

Summary of the AOP Events: Molecular Initiating Events (MIE) Key Events (KE) Adverse Outcomes (AO) Relationships Between Two Key Events (Including MIEs and AOs) Network View Prototypical Stressors Life Stage Applicability Taxonomic Applicability Sex Applicability Overall Assessment of the AOP Biological plausibility, empirical support and quantitative understanding of the KERs and the evidence that uphold essentialities of KEs in this AOP were analyzed together for the overall assessment of an AOP