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The master chondrogenic transcription factor Sox9 on the one hand promotes glutamine utilization and on the other hand suppresses fatty acid oxidation, thus orchestrating major metabolic rewiring necessary for chondrogenesis

[91] demonstrated lower expression of phosphorylated NF-kB in macrophages cultivated with higher concentrations of glutamine and stimulated with LPS, showing that glutamine negatively regulated NF-kB signaling pathway

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