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Furthermore, nicotine has garnered significant attention among natural compounds in clinical trials for PD therapy, with three completed studies focusing on its neuroprotective effects and improvements in motor and cognitive symptoms (www.ClinicalTrials.gov, Identifier: NCT03865121, NCT02452125, and NCT00873392)

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Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

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