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Supplementary Figure S3 illustrates the spatial interplay of cofactor and substrate in the MSA-DH active site on the basis of the NAD(P) + and the MSA funnel

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In cancer, the delicate balance of proteostasis is often disrupted, leading to the accumulation of misfolded or damaged proteins, aberrant signaling pathways, and genomic instability, all of which contribute to tumorigenesis and cancer progression

e496 (2019)