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These mouse studies appear relevant to human disease, as a large number of studies have shown that polymorphisms in PON1 are associated with increased risk for atherosclerosis (265)

Ann Intern Med 86:24, 1977

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Zhu J., Zhao B., Xiong P., Wang C., Zhang J., Tian X., Huang Y

Step 3: Decarboxylation of Glutamate The final step involves decarboxylation of glutamate, where a carboxyl group (-COOH) is removed from the molecule to form GABA