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84 The topical application of vasodilators provides pain relief in PDPN, suggesting a role for hypoxia and/or vascular dysfunction in the generation of neuropathic pain in DPN

Epitalon, also known as epithalamin or epithalon, is a synthetic tetrapeptide composed of Ala-Glu-Asp-Gly, derived from a naturally occurring pineal gland extract called epithalamin