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Little is known about the correlation of non-invasive tests in relation to the spatial distribution of collagen in the liver

2019 doi: 10.1155/2019/5832410

In IPF, environmental factors such as cigarette smoke, air pollution, and microbial infections damage alveolar epithelial cells (AECs) and microvascular endothelial cells, initiating an aberrant injuryrepair cascade [33,34,35]

Therefore, to investigate the mechanistic link between fumarate accumulation, succination of GSH, and oxidative stress, respiration-competent Fh1 fl/fl cells were incubated with a cell-permeable derivative of fumarate, dimethylfumarate (DMF)