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B12 supplements are known to play a crucial role in maintaining healthy nerve cells, which are essential for cognitive function

Environ Res, 22(2): 439-449

It has since become appreciated that mitochondrial matrix Ca 2+ concentrations are crucial regulators of the Ca 2+ dependent enzymes of the TCA cycle ( 2+ buffering ( Mitochondria act as Ca 2+ buffers through uptake of Ca 2+ released by IP 3 R on proximal ER membranes (Figure 2)