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Blown veins leak blood, causing skin to darken around the injection site

Treatments with HU or with other -globin inducers, either alone or in combination, have been shown to increase Hb levels by 15 g/dL [188]

The mechanism behind dark circles under the eyes due to fatigue is based on physiological principles: Sleep deprivation causes skin to become pale and the veins under the thin skin of the under-eye area to become more prominent

Some of the most common secondary causes include: Endometriosis This disorder occurs when tissue similar to the tissue that normally lines the inside of your uterus grows outside your uterus, often adhering to your bladder, ovaries, or even your bowels